Expression of Cadherin Superfamily Genes During Ferret Brain Development

This book PDF is perfect for those who love Electronic Books genre, written by Krishna-K. Muthukumarappan and published by Unknown which was released on 29 March 2024 with total hardcover pages 0. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related Expression of Cadherin Superfamily Genes During Ferret Brain Development books below.

Expression of Cadherin Superfamily Genes During Ferret Brain Development
Author : Krishna-K. Muthukumarappan
File Size : 40,6 Mb
Publisher : Unknown
Language : English
Release Date : 29 March 2024
ISBN : OCLC:436306321
Pages : 0 pages
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Expression of Cadherin Superfamily Genes During Ferret Brain Development by Krishna-K. Muthukumarappan Book PDF Summary

Cadherins are a superfamily of Ca2+-dependent cell adhesion molecules with more than 100 members (Redies et al., 2005). They are multifunctional transmembrane glycoproteins found in several kinds of cell-cell contact, including adherens junctions. They regulate a wide variety of crucial developmental mechanisms, including cell proliferation, cell differentiation, cell-cell recognition, neurite outgrowth, synaptogenesis and angiogenesis. In this study, I cloned eighteen novel members of the classic cadherin and delta-protocadherin subgroups and investigated their expression patterns by in situ hybridization from the brain of ferret, an animal model suitable for visual cortical and cerebrovascular research. I also showed seven members of the cadherin superfamily and an intracellular binding partner of delta-protocadherins, protein phosphatase 1alpha? as novel markers for developing blood vessels in the ferret brain. Some of the cadherin molecules are restricted to specific brain regions or a subset of blood vessels. The expression levels show a peak during perinatal vascular development. My results suggest that multiple cadherins, which are also involved in neurogenesis, are regulators of angiogenesis in developing vertebrate brain, supporting the idea of a common mechanism behind "neuroangiogenesis".

Expression of Cadherin Superfamily Genes During Ferret Brain Development

Cadherins are a superfamily of Ca2+-dependent cell adhesion molecules with more than 100 members (Redies et al., 2005). They are multifunctional transmembrane glycoproteins found in several kinds of cell-cell contact, including adherens junctions. They regulate a wide variety of crucial developmental mechanisms, including cell proliferation, cell differentiation, cell-cell recognition, neurite outgrowth,

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