Pyrazole Based Drug Discovery

This book PDF is perfect for those who love Science genre, written by Nachiket S. Dighe and published by Elsevier which was released on 15 June 2021 with total hardcover pages 370. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related Pyrazole Based Drug Discovery books below.

Pyrazole Based Drug Discovery
Author : Nachiket S. Dighe
File Size : 47,8 Mb
Publisher : Elsevier
Language : English
Release Date : 15 June 2021
ISBN : 0128241403
Pages : 370 pages
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Pyrazole Based Drug Discovery by Nachiket S. Dighe Book PDF Summary

Pyrazole-Based Drug Discovery outlines the complexities of the pyrazole scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Designed as a guide for both experts and students working in this and related areas, this volume will facilitate the continued design and development of novel pharmaceuticals based on pyrazole and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. Pyrazole is a novel heterocycle with anti-fungal, antimicrobial, anti-tubercular, and antipsychotic pharmacological activities, proving to be a promising agent for medicinal chemists to synthesize various new chemical entities with desired biological activities. This book is ideal for researchers working in organic and medicinal chemistry both in academia and industry. Explores this extremely important heterocycle in a high level of detail Describes synthesis methods for current drugs based on pyrazole scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing pyrazole Provides pharmacologists a solid overview of the chemical background of existing pyrazole-based drugs

Pyrazole Based Drug Discovery

Pyrazole-Based Drug Discovery outlines the complexities of the pyrazole scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Designed as a guide for both experts and students working in this and related areas, this volume will facilitate the continued design and development of

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Pyrazole  Preparation and Uses

This book has comprehensively reviewed the latest information on pyrazoles, their preparations and uses. It provides extended ideas on pyrazole and its derivatives including their synthesis, chemistry, structure activity relationship (SAR) and therapeutic applications. The health promoting properties of these pyrazoles are discussed in this book with different therapeutic applications

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Privileged Scaffolds in Medicinal Chemistry

This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.

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This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well

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Heterocyclic Chemistry in Drug Discovery

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the

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Privileged Structures in Drug Discovery

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that

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Synthetic Methods in Drug Discovery

The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads

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Drug Discovery for Leishmaniasis

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the

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