Technologies for Detection of DNA Damage and Mutations

This book PDF is perfect for those who love Science genre, written by G.P. Pfeifer and published by Springer Science & Business Media which was released on 11 November 2013 with total hardcover pages 443. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related Technologies for Detection of DNA Damage and Mutations books below.

Technologies for Detection of DNA Damage and Mutations
Author : G.P. Pfeifer
File Size : 42,5 Mb
Publisher : Springer Science & Business Media
Language : English
Release Date : 11 November 2013
ISBN : 9781489903013
Pages : 443 pages
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Technologies for Detection of DNA Damage and Mutations by G.P. Pfeifer Book PDF Summary

Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exposure to a carcinogen, tumor develop ment, and genetic changes in tumor DNA have been established. To understand mutagenesis processes in more detail at the molecular level, we need to know the type and frequency of DNA adducts within cells, their distribution along genes and specific DNA sequences, as well as the rates at which they are repaired. We also need to know what types of mutations are produced and which gene positions are most prone to mutagenesis. This book provides a collection of techniques that are useful in mutagenesis research. The book is divided into three parts. In Part I, methods for DNA damage and repair analysis are provided.

Technologies for Detection of DNA Damage and Mutations

Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote

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Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive.

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