The DNA Damage Response Implications on Cancer Formation and Treatment

This book PDF is perfect for those who love Medical genre, written by Kum Kum Khanna and published by Springer Science & Business Media which was released on 18 September 2009 with total hardcover pages 449. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related The DNA Damage Response Implications on Cancer Formation and Treatment books below.

The DNA Damage Response  Implications on Cancer Formation and Treatment
Author : Kum Kum Khanna
File Size : 44,7 Mb
Publisher : Springer Science & Business Media
Language : English
Release Date : 18 September 2009
ISBN : 9048125618
Pages : 449 pages
Get Book

The DNA Damage Response Implications on Cancer Formation and Treatment by Kum Kum Khanna Book PDF Summary

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

The DNA Damage Response  Implications on Cancer Formation and Treatment

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “

Get Book
Targeting the DNA Damage Response for Anti Cancer Therapy

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It

Get Book
Targeting the DNA Damage Response for Cancer Therapy

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic

Get Book
Cancer Associated Defects in the DNA Damage Response  Drivers for Malignant Transformation and Potential Therapeutic Targets

For this eBook, and the associated Research Topic in Frontiers in Genetics, entitled: ‘Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets’ we have selected 10 papers that each discusses important, yet distinct aspects of the response to DNA damage in normal cells and cancer

Get Book
Molecular Biology of Prostate Cancer

In this volume, international experts discuss the following topics: molecular principles of the genesis of prostate cancer and the involvement of oncogenes and tumor suppressor genes; changes of cell-cell contacts; defects in androgen receptors and their effect on treatment with antiandrogens; drug resistance mechanisms and new therapeutic principles; molecular diagnosis

Get Book
Exploiting DNA Damage Response in the Era of Precision Oncology

Topic Editor Christian Reinhardt has received funding from companies Gilead, and lecture fees from Abbvie, Merck, and AstraZeneca. All other topic editors declare no competing interests with regards to the Research Topic subject.

Get Book
Advances in DNA Repair in Cancer Therapy

​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of

Get Book