Cytotoxic Payloads for AntibodyDrug Conjugates

This book PDF is perfect for those who love Medical genre, written by David E Thurston and published by Royal Society of Chemistry which was released on 11 July 2019 with total hardcover pages 480. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related Cytotoxic Payloads for AntibodyDrug Conjugates books below.

Cytotoxic Payloads for AntibodyDrug Conjugates
Author : David E Thurston
File Size : 51,7 Mb
Publisher : Royal Society of Chemistry
Language : English
Release Date : 11 July 2019
ISBN : 9781788018456
Pages : 480 pages
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Cytotoxic Payloads for AntibodyDrug Conjugates by David E Thurston Book PDF Summary

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Cytotoxic Payloads for AntibodyDrug Conjugates

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in

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