| Author | : Hiroshi Maruta |
| File Size | : 50,7 Mb |
| Publisher | : Landes Bioscience |
| Language | : English |
| Release Date | : 02 May 1998 |
| ISBN | : NWU:35558004225864 |
| Pages | : 408 pages |
G Proteins Cytoskeleton and Cancer by Hiroshi Maruta Book PDF Summary
Building upon the pioneering work of Klaus Weber, who in the 1970s discovered a key to the malignant transformation of normal cells by tumor virus infection or mutations via the disruption of actin cables and subsequent induction of membrane ruffling occurring with oncogenes such as v-Ras and v-Src, the global contributors aim toward the quantum leap of creating an anticancer Holy Grail that would attenuate the malignant activity of oncogenic mutants. The two dozen papers are organized under the four major headings of: actin-cytoskeleton, Ras/Rho family GTPases, links between G proteins and actin, and new anticancer drugs (e.g. farnesyltransferase inhibitors, SCH51344, and azatyrosine). Annotation copyrighted by Book News, Inc., Portland, OR