Inhibitors of Molecular Chaperones as Therapeutic Agents

This book PDF is perfect for those who love Medical genre, written by Timothy D. Machajewski and published by Royal Society of Chemistry which was released on 30 May 2024 with total hardcover pages 443. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related Inhibitors of Molecular Chaperones as Therapeutic Agents books below.

Inhibitors of Molecular Chaperones as Therapeutic Agents
Inhibitors of Molecular Chaperones as Therapeutic Agents
Author : Timothy D. Machajewski
File Size : 49,9 Mb
Publisher : Royal Society of Chemistry
Language : English
Release Date : 30 May 2024
ISBN : 9781849736664
Pages : 443 pages
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Inhibitors of Molecular Chaperones as Therapeutic Agents by Timothy D. Machajewski Book PDF Summary

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.

Inhibitors of Molecular Chaperones as Therapeutic Agents

Inhibitors of Molecular Chaperones as Therapeutic Agents by Timothy D. Machajewski,Zhenhai Gao

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by

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Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell

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Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it

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