| Author | : Alessandra Stasi |
| File Size | : 42,5 Mb |
| Publisher | : Frontiers Media SA |
| Language | : English |
| Release Date | : 17 November 2023 |
| ISBN | : 9782832539040 |
| Pages | : 124 pages |
Community Series in New Insights in Sepsis Pathogenesis and Renal Dysfunction Immune Mechanisms and Novel Management Strategies volume II by Alessandra Stasi Book PDF Summary
This Research Topic is the second volume of the “New Insights in Sepsis Pathogenesis and Renal Dysfunction: Immune Mechanisms and Novel Management Strategies” Community Series. Please see the first volume here. Sepsis is a systemic inflammatory response to an active infectious process in the host; the symptoms are mainly produced by host defense systems rather than by the invading pathogens, involving pro-inflammatory and anti-inflammatory processes. The association of Acute Kidney Injury (AKI) and sepsis ranges from 45% to 70% of cases, with a significantly increased risk of death, progression toward chronic kidney disease and increased health resource utilization. Despite relevant therapeutic advances, sepsis-related AKI remains associated with an unacceptably high morbidity/mortality risk, increased health resource utilization, as well as - in survivors - with increased risk of transition to chronic kidney disease. Currently there are no approved treatments for sepsis-related AKI. The main objective of this research topic is to shed new light on sepsis pathogenesis and provide new potential therapeutic strategies to prevent the progression to AKI.