OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay
OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay
Author : OECD
File Size : 46,6 Mb
Publisher : OECD Publishing
Language : English
Release Date : 30 June 2022
ISBN : 9789264366060
Pages : 37 pages
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OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay by OECD Book PDF Summary

This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.

OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay

OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay by OECD

This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes

OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes by OECD

The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene by OECD

This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.

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Test No 474 Mammalian Erythrocyte Micronucleus Test

Test No 474 Mammalian Erythrocyte Micronucleus Test by OECD

The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

OECD Guidelines for the Testing of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays by OECD

This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay

OECD Guidelines for the Testing of Chemicals Section 4 Test No 485 Genetic toxicology Mouse Heritable Translocation Assay by OECD

The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells

OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells by OECD

The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 480 Genetic Toxicology Saccharomyces cerevisiae Gene Mutation Assay

OECD Guidelines for the Testing of Chemicals Section 4 Test No 480 Genetic Toxicology Saccharomyces cerevisiae Gene Mutation Assay by OECD

This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...

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