| Author | : David J. Matthews |
| File Size | : 42,5 Mb |
| Publisher | : John Wiley & Sons |
| Language | : English |
| Release Date | : 20 September 2011 |
| ISBN | : 9781118210772 |
| Pages | : 720 pages |
Targeting Protein Kinases for Cancer Therapy by David J. Matthews Book PDF Summary
An expert guide to targeting protein kinases in cancertherapy Research has shown that protein kinases can instigate theformation and spread of cancer when they transmit faulty signalsinside cells. Because of this fact, pharmaceutical scientists havetargeted kinases for intensive study, and have been working todevelop medicinal roadblocks to sever their malignant means ofcommunication. Complete with full-color presentations, Targeting ProteinKinases for Cancer Therapy defines the structural features ofprotein kinases and examines their cellular functions. Combiningkinase biology with chemistry and pharmacology applications, thisbook enlists emerging data to drive the discovery of newcancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved inoncology, integrating protein structure and function, and providingimportant tools to assist pharmaceutical researchers to understandand work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeuticmodalities Discussion of kinase inhibitors that have entered clinicaltrials for the treatment of cancer, with an emphasis on moleculesthat have progressed to late stage clinical trials and, in a fewcases, to market Providing a platform for further study, this important workreviews both the successes and challenges of kinase inhibitortherapy, and provides insight into future directions in the waragainst cancer.