Tyrosine Kinases as Druggable Targets in Cancer

This book PDF is perfect for those who love Medical genre, written by Huan Ren and published by BoD – Books on Demand which was released on 25 September 2019 with total hardcover pages 136. You could read this book directly on your devices with pdf, epub and kindle format, check detail and related Tyrosine Kinases as Druggable Targets in Cancer books below.

Tyrosine Kinases as Druggable Targets in Cancer
Tyrosine Kinases as Druggable Targets in Cancer
Author : Huan Ren
File Size : 44,5 Mb
Publisher : BoD – Books on Demand
Language : English
Release Date : 25 September 2019
ISBN : 9781789848083
Pages : 136 pages
Get Book

Tyrosine Kinases as Druggable Targets in Cancer by Huan Ren Book PDF Summary

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment.

Tyrosine Kinases as Druggable Targets in Cancer

Tyrosine Kinases as Druggable Targets in Cancer by Huan Ren

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management.

Get Book
Protein Tyrosine Kinases

Protein Tyrosine Kinases by Doriano Fabbro,Frank McCormick

Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights

Get Book
Protein Kinases

Protein Kinases by Anonim

For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways

Get Book
Protein Kinases as Drug Targets

Protein Kinases as Drug Targets by Bert Klebl,Gerhard Müller,Michael Hamacher

This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current

Get Book
Extracellular Targeting of Cell Signaling in Cancer

Extracellular Targeting of Cell Signaling in Cancer by James W. Janetka,Roseann M. Benson

International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy.

Get Book
Receptor Tyrosine Kinases Family and Subfamilies

Receptor Tyrosine Kinases Family and Subfamilies by Deric L. Wheeler,Yosef Yarden

This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with

Get Book
Targeting Protein Kinases for Cancer Therapy

Targeting Protein Kinases for Cancer Therapy by David J. Matthews,Mary E. Gerritsen

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal

Get Book
Molecules Engineered Against Oncogenic Proteins and Cancer

Molecules Engineered Against Oncogenic Proteins and Cancer by E. J. Corey,Yong-Jin Wu

Molecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine’s most challenging

Get Book