| Author | : Zheng Wang |
| File Size | : 40,8 Mb |
| Publisher | : Frontiers Media SA |
| Language | : English |
| Release Date | : 22 February 2024 |
| ISBN | : 9782832545065 |
| Pages | : 132 pages |
Novel molecular mechanisms and clinical strategies in solid tumor recurrence and metastasis from bench to bedside by Zheng Wang Book PDF Summary
Recurrence and metastasis of malignancy is a multistep process that involves the escape of tumor cells from the primary location, systemic translocation in the body, and adaptation to the foreign microenvironment of distant sites. The spread of cancer cells is mediated by the interaction between tumor cells (seeds) and the microenvironment of the host organ (soil). Emerging evidence has revealed several stages of the invasion-metastasis cascade, including epithelial-mesenchymal transition, angiogenesis, and immune surveillance escape. Moreover, host organs could develop premetastatic niches and be more vulnerable to cancer cell colonization, adaptation and growth.