| Author | : Philip R. Dormitzer |
| File Size | : 49,6 Mb |
| Publisher | : Springer Science & Business Media |
| Language | : English |
| Release Date | : 02 November 2010 |
| ISBN | : 9783034602778 |
| Pages | : 447 pages |
Replicating Vaccines by Philip R. Dormitzer Book PDF Summary
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.