OECD Guidelines for the Testing of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test
OECD Guidelines for the Testing of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test
Author : OECD
File Size : 42,8 Mb
Publisher : OECD Publishing
Language : English
Release Date : 04 July 2023
ISBN : 9789264264861
Pages : 30 pages
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OECD Guidelines for the Testing of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test by OECD Book PDF Summary

The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.

OECD Guidelines for the Testing of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test

OECD Guidelines for the Testing of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test by OECD

The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.

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Test No 487 In Vitro Mammalian Cell Micronucleus Test

Test No 487 In Vitro Mammalian Cell Micronucleus Test by OECD

The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...

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Test No 474 Mammalian Erythrocyte Micronucleus Test

Test No 474 Mammalian Erythrocyte Micronucleus Test by OECD

The mammalian in vivo micronucleus test detects damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals.

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes

OECD Guidelines for the Testing of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes by OECD

The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 482 Genetic Toxicology DNA Damage and Repair Unscheduled DNA Synthesis in Mammalian Cells in vitro

OECD Guidelines for the Testing of Chemicals Section 4 Test No 482 Genetic Toxicology DNA Damage and Repair Unscheduled DNA Synthesis in Mammalian Cells in vitro by OECD

The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay

OECD Guidelines for the Testing of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig a Gene Mutation Assay by OECD

This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

OECD Guidelines for the Testing of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene by OECD

This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.

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OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells

OECD Guidelines for the Testing of Chemicals Section 4 Test No 479 Genetic Toxicology In vitro Sister Chromatid Exchange Assay in Mammalian Cells by OECD

The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...

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